Agomelatine ( Form I & Premix )

Product Description:

Agomelatine is a melatonergic antidepressant active pharmaceutical ingredient supplied as a white to off-white crystalline powder for use in pharmaceutical formulations. It exerts its pharmacological activity through agonistic action at melatonin MT₁ and MT₂ receptors and antagonism at serotonin 5-HT₂C receptors, thereby modulating circadian rhythms and enhancing dopaminergic and noradrenergic transmission in the frontal cortex, supporting the management of mood disorders associated with circadian dysregulation.

As a novel antidepressant with a unique dual mechanism, Agomelatine offers distinct formulation and therapeutic positioning compared to conventional monoamine-based antidepressants, particularly in applications where circadian rhythm alignment and improved tolerability are key considerations. Its physicochemical profile supports incorporation into oral solid dosage forms such as tablets designed for consistent release and patient adherence. The API is packaged in double LDPE bags within HDPE drums or equivalent pharma-grade, light- and moisture-protective containers to maintain stability under recommended storage conditions.

As a leading distribution partner, Molkem Chemicals ensures reliable supply of products aligned with industry quality standards and regulatory expectations. Each product is delivered as per agreed specifications, supported by standard documentation including COA, SDS, and TDS. If required, our technical team can provide additional stability data and regulatory assistance.